PMC

A. Histogram of distribution of percentage of ciliated epithelial cells in GSE135893 (Kropski-Vanderbilt Univ single cell cohort) [] with the cutoff we selected indicated. B-E. Circular plots indicating ligand receptor interactions in subsets of patients in GSE135893 (Kropski-Vanderbilt Univ single cell cohort) []. On each circular plot, the top half of the circle represents cell types expressing the receptor for the ligand of the indicated cell type on the bottom half of the plot. Connections represent inferred active ligand-receptor pairs between types of cells. The thickness of the lines represents the relative level of expression of a given ligand/receptor. Transparency of the lines represents relative strength of the given ligand-receptor interaction as reported by the z score value calculated by PyMiner. B. Top ligands produced by macrophages (bottom half of circle) in ‘Ciliated_low’ patients and the top receptors they interact with (top half of circle with cell types expressing the receptor indicated). C. Top ligands produced by macrophages (bottom half of circle) in ‘Ciliated_high’ patients and the top receptors they interact with (top half of circle with cell types expressing the receptor indicated). D. Top ligands produced by ciliated epithelial cells (bottom half of circle) in ‘Ciliated_low’ patients and the top receptors they interact with (top half of circle with cell types expressing the receptor indicated). E. Top ligands produced by ciliated epithelial cells (bottom half of circle) in ‘Ciliated_high’ patients and the top receptors they interact with (top half of circle with cell types expressing the receptor indicated).

Synergy from silence. A, Distribution of synergy values of the 1 ⊗ 0 symbol for natural movies (top, 5497 cell pairs), checkerboard movies (middle, 688 pairs) and uniform flicker (683 pairs). Top panel also shows the distribution of maximum 1 ⊗ 0 synergies for each cell found by pairing it with its most informative silent partner (black). B, Distribution of synergy values of 1 ⊗ 0 ⊗ 0 (top) and 1 ⊗ 0 ⊗ 0 ⊗ 0 symbols (middle) for salamander and 1 ⊗ 0 ⊗ 0 ⊗ 0 (bottom) for guinea pig under naturalistic stimulation. C, D, Synergy of 1 ⊗ 0 ⊗ 0 ⊗ 0 symbols compared to the sum of synergy values of the corresponding three synergies of 1 ⊗ 0 symbols for (salamander, guinea pig) under naturalistic stimulation. Error bars omitted for clarity.

a Mass increments of substrates and products over time: sum of substrates (filled square), mass of bottom phase (filled circle), mass of top phase (open circle). b Phase-forming components in phases over time: phosphate in bottom phase (filled square), PEG in bottom phase (filled circle), phosphate in top phase (open square), PEG in top phase (open circle). c Laccase activities in phases over time: bottom phase (filled circle), top phase (open circle). d Efficiency parameters over time: bottom phase concentration factor (filled circle), bottom phase yield (open circle)

Neural markers of negative emotion across self-criticism and self-reassurance. Negative Emotion during Self-Criticism: Left. Sagittal image of MPFC (Left Circle), ACC (Middle Circle), and Left Lingual Gyrus and Cerebellum (Right Circle). Right. Axial image of Subcortical Regions (Top Circle) and Bilateral Visual Cortex (Bottom Circle). Negative Emotion during Self-Reassurance: Left. Sagittal image of MPFC (Left Circle) and Visual Cortex (Right Circle). Right. Axial image of Visual Cortex. Negative Emotion during Self-Criticism—Negative Emotion during Self-Reassurance: Top Left. Sagittal image of ACC. Top Right. Sagittal image of posterior cingulate. Bottom Left. Axial image of left putamen. Bottom Right. Axial image of Right Hippocampus. Coordinates reported in MNI-space. N = 40.